It may not be an exact match, but in general you could probably get away with this type of layout just using Hype's Flexible Layout combined with Responsive Layouts. Here's an example I see that looks somewhat similar and uses both techniques jointly:
If you actually want to use the CSS flexbox constructs in conjunction with Hype, that is a little trickier. Often these need parent/child relationships that Hype prefers to manage itself, and then also Hype really wants everything to have absolute layouts.
I believe @MaxZieb (and perhaps others?) have done some work on these types of layouts - Hype AutoLayout, Hype LayoutKit, Hype GridBuilder. There's might be some other examples out there too...?