If you use flexible layout, you can setup elements to individually change their positioning within. It is similar to the group. The trick is that you need the persistent symbol element itself to have flexible layout setup, and you then need any parent groups also setup - basically flexible layout settings need to go all the way down as it would with a normal group. That said, sometimes it is easier to use "zoom contents" on the persistent symbol element.
Just as a reminder, the symbol element itself is different in each layout/scene, so they can have their own settings. However items inside are all identical due to the nature of being a symbol.