Well, where's the problem exactly? Does it have to be a single file?
If that's the problem, I did some research here...
I was trying to automate the process of converting a Hype project into a single HTML file. The general theory is if the Hype Runtime, and generated JavaScript code, was cut-and-pasted into the document, and the images were converted to Base64, it might work? I don't know. I lost interest, as I was more focused on automation.
I was looking at features Hype doesn't have, but something that Flash could do — export a whole project to a single file.
However, I'm able to export an entire Hype project to an app with Wrapping. It's not clear to me if “apps” can be part of this NFT thing.
I haven't used Opensea, or NFTs / Cryptocurrency in general, but I read something about Mintable being used for ePub…
I'm not sure about this tech though. It's still quite strange and alien to me. I'm not sure of the point. People are paying money for GIFs, PNGs ands JPGs?! WHY?!
What does one do with these images? This doesn't make any sense to me. 
I do get that impression. Heh, it's like the Wild West. It does seem like Cryptocurrency has the potential to be one of the next big things in tech. So, instead of looking at Hype as a replacement for Flash, by comparing Hype to features of Flash, the key is to realize that Flash made it big because of the time it was released.
Websites were the 90s & 2000s,
Apps were the 2010s,
Is this the Crytpo era of the Internet? 